6-氯-1氢-吡唑并[3,4-B]吡啶合成路线 （共 3 条）
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 1.2: 2 h / -78 °C 2.1: toluene-4-sulfonic acid / toluene / 1 h / |Reflux 3.1: hydrazine hydrate / butan-1-ol / 1 h / 150 °C / |Sealed tube View Scheme
反应条件
1: toluene-4-sulfonic acid / toluene / 1 h / |Reflux 2: hydrazine hydrate / butan-1-ol / 1 h / 150 °C / |Sealed tube View Scheme
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Fernandez Collado, Juan Carlos; Erra Sola, Montserrat; Aguilar Izquierdo, Nuria; Mir Cepeda, Marta; Carranco Moruno, Inés
Patent: EP2489663 A1, 2012 ;
Location in patent: Paragraph 0772; 0773; 0774 ;
EP 2489663 A1
