2-(苄氧基)-5-氯苯胺合成路线 （共 10 条）
反应条件
di-tert-butyl peroxide; FeBr2 in benzene T=110°C; Schlenk techniqueInert atmosphere;
参考文献
Gu, Lijun; Wang, Wei; Xiong, Yong; Huang, Xiangzhong; Li, Ganpeng
European Journal of Organic Chemistry, 2014 , vol. 2014, # 2 p. 319 - 322
反应条件
ueber die Diazonium-Verbindung;
参考文献
Buchan; McCombie
Journal of the Chemical Society, 1931 , p. 137,144
反应条件
1: aqueous sulfuric acid; sodium nitrite; copper
2: potassium permanganate; acetone
View Scheme
参考文献
Cavill et al.
Journal of the Chemical Society, 1958 , p. 1544,1548
反应条件
zinc in acetic acid
T=20°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/37786 A1, 2005 ;
Location in patent: Page/Page column 31-32 ;
WO 2005/037786 A1
反应条件
water; hydrazine in ethanol
2 h; Reflux;
参考文献
Li, Yue; Chen, Shu-Han; Ou, Tian-Miao; Tan, Jia-Heng; Li, Ding; Gu, Lian-Quan; Huang, Zhi-Shu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 2074 - 2083
反应条件
1: With potassium carbonate in acetone
20 h; Reflux;
2: With hydrogenchloride in dichloromethane; water
1 h;
参考文献
Wang, Renchao; Xu, Jiaxi
Arkivoc, 2010 , vol. 2010, # 9 p. 293 - 299
反应条件
1: acetic acid / 2 h / Reflux
2: potassium carbonate / acetone / 3 h / Reflux
3: water; hydrazine / ethanol / 2 h / Reflux
View Scheme
参考文献
Li, Yue; Chen, Shu-Han; Ou, Tian-Miao; Tan, Jia-Heng; Li, Ding; Gu, Lian-Quan; Huang, Zhi-Shu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 2074 - 2083
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C
2: ammonium chloride; zinc / water; methanol / 1 h / 20 °C
View Scheme
参考文献
ALLERGAN, INC.; YUAN, HAIQING; BEARD, RICHARD L.; LIU, XIAOXIA; DONELLO, JOHN E.; VISWANATH, VEENA; GARST, MICHAEL E.
Patent: US2013/231338 A1, 2013 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C
2: ammonium chloride; zinc / water; methanol / 1 h / 20 °C
View Scheme
参考文献
ALLERGAN, INC.; YUAN, HAIQING; BEARD, RICHARD L.; LIU, XIAOXIA; DONELLO, JOHN E.; VISWANATH, VEENA; GARST, MICHAEL E.
Patent: US2013/231338 A1, 2013 ;
反应条件
1: durch Benzylierung
2: durch Reduktion
View Scheme
参考文献
Hoechster Farbw.
Patent: DE142899 ;
