4H-1,4-苯并二氮-4,8-二羧酸-1,2,3,5-四氢-2-氧代-4-(1,1-二甲基乙基)酯合成路线 （共 6 条）
反应条件
anhydrous potassium trimethylsilanolate in tetrahydrofuran
T=40°C; 2 h;
参考文献
Hone, Neal D.; Wilson, William; Reader, John C.
Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8493 - 8495
反应条件
1: HCl / 18 h / 20 °C
2: DIEA / dimethylformamide / 18 h / 20 °C
3: CH2Cl2 / 18 h / 20 °C
4: H2 / Pd / tetrahydrofuran; methanol / 72 h / 20 °C / 760 Torr
5: toluene / Heating
6: potassium trimethylsilanolate / tetrahydrofuran / 2 h / 40 °C
View Scheme
参考文献
Hone, Neal D.; Wilson, William; Reader, John C.
Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8493 - 8495
反应条件
1: DIEA / dimethylformamide / 18 h / 20 °C
2: CH2Cl2 / 18 h / 20 °C
3: H2 / Pd / tetrahydrofuran; methanol / 72 h / 20 °C / 760 Torr
4: toluene / Heating
5: potassium trimethylsilanolate / tetrahydrofuran / 2 h / 40 °C
View Scheme
参考文献
Hone, Neal D.; Wilson, William; Reader, John C.
Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8493 - 8495
反应条件
1: CH2Cl2 / 18 h / 20 °C
2: H2 / Pd / tetrahydrofuran; methanol / 72 h / 20 °C / 760 Torr
3: toluene / Heating
4: potassium trimethylsilanolate / tetrahydrofuran / 2 h / 40 °C
View Scheme
参考文献
Hone, Neal D.; Wilson, William; Reader, John C.
Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8493 - 8495
反应条件
1: H2 / Pd / tetrahydrofuran; methanol / 72 h / 20 °C / 760 Torr
2: toluene / Heating
3: potassium trimethylsilanolate / tetrahydrofuran / 2 h / 40 °C
View Scheme
参考文献
Hone, Neal D.; Wilson, William; Reader, John C.
Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8493 - 8495
反应条件
1: toluene / Heating
2: potassium trimethylsilanolate / tetrahydrofuran / 2 h / 40 °C
View Scheme
参考文献
Hone, Neal D.; Wilson, William; Reader, John C.
Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8493 - 8495
