3-溴-2-羟基-5-碘吡啶合成路线 （共 2 条）
反应条件
N-iodo-succinimide in acetonitrile; trifluoroacetic acid
T=20°C; 15 h;
参考文献
GENENTECH, INC.; Crawford, James John; Ortwine, Daniel Fred; Wei, BinQing; Young, Wendy B.
Patent: US2013/116246 A1, 2013 ;
Location in patent: Paragraph 0467 ;
反应条件
1.1: s-BuLi / -90 °C
1.2: 71 percent / H2O / -90 °C
2.1: 92 percent / NIS / acetonitrile / 1 h / Heating
View Scheme
参考文献
Meana, Angela; Rodriguez, Justo F.; Sanz-Tejedor, M. Ascension; Garcia-Ruano, Jose L.
Synlett, 2003 , # 11 p. 1678 - 1682
