3,4-(亚甲基二氧)苯丁酮合成路线 （共 5 条）
反应条件
boron trifluoride in 1,2-dichloro-ethane T=-15 - -5°C; Large scale;
参考文献
Storace, Louis; Anzalone, Luigi; Confalone, Pat N.; Davis, Wayne P.; Fortunak, Joseph M.; Giangiordano, Mark; Haley Jr., James J.; Kamholz, Kenneth; Li, Hui-Yin; Ma, Philip; Nugent, William A.; Parsons Jr., Rodney L.; Sheeran, Patrick J.; Silverman, Charlotte E.; Waltermire, Robert E.; Wood, Christopher C.
Organic Process Research and Development, 2002 , vol. 6, # 1 p. 54 - 63
反应条件
1: (S)-oxazaborolidine-borane complex 2: diphenylphosphoryl azide, DBU / toluene / 0-5 deg C -> room temperature 2-3 h, 16 h 3: LiAlH4 / tetrahydrofuran; toluene / 8 h / 23 °C 4: 98 percent / HCl / toluene / 1.33 h / 100 °C 5: 80 percent / DBU / acetonitrile / 1 h View Scheme
参考文献
Cvetovich, Raymond J.; Chartrain, Michel; Hartner Jr., Frederick W.; Roberge, Christopher; Amato, Joseph S.; Grabowski, Edward J. J.
Journal of Organic Chemistry, 1996 , vol. 61, # 19 p. 6575 - 6580
反应条件
1: methanol / 60 °C / |Inert atmosphere 2: potassium carbonate; methanol; hydrogen; palladium 10 on activated carbon / 24 h / 65 °C / 760.05 Torr View Scheme
参考文献
Zhou, Lei; Liu, Zhenxing; Liu, Yizhou; Zhang, Yan; Wang, Jianbo
Tetrahedron, 2013 , vol. 69, # 30 p. 6083 - 6087
反应条件
1: (S)-oxazaborolidine-borane complex
2: diphenylphosphoryl azide, DBU / toluene / 0-5 deg C -> room temperature 2-3 h, 16 h
3: LiAlH4 / tetrahydrofuran; toluene / 8 h / 23 °C
View Scheme
参考文献
Cvetovich, Raymond J.; Chartrain, Michel; Hartner Jr., Frederick W.; Roberge, Christopher; Amato, Joseph S.; Grabowski, Edward J. J.
Journal of Organic Chemistry, 1996 , vol. 61, # 19 p. 6575 - 6580
反应条件
1: (S)-oxazaborolidine-borane complex
2: diphenylphosphoryl azide, DBU / toluene / 0-5 deg C -> room temperature 2-3 h, 16 h
3: LiAlH4 / tetrahydrofuran; toluene / 8 h / 23 °C
4: 98 percent / HCl / toluene / 1.33 h / 100 °C
View Scheme
参考文献
Cvetovich, Raymond J.; Chartrain, Michel; Hartner Jr., Frederick W.; Roberge, Christopher; Amato, Joseph S.; Grabowski, Edward J. J.
Journal of Organic Chemistry, 1996 , vol. 61, # 19 p. 6575 - 6580
