(R)-2-羟基-2-甲基苯丙酸合成路线 （共 22 条）
反应条件
trifluoroacetic acid
T=20°C; 0.166667 h;
参考文献
Diez, Elena; Dixon, Darren J.; Ley, Steven V.
Angewandte Chemie - International Edition, 2001 , vol. 40, # 15 p. 2906 - 2909
反应条件
hydrogenchloride in water
3 h; Heating;
参考文献
Wang, Mei-Xiang; Deng, Gang; Wang, De-Xian; Zheng, Qi-Yu
Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2439 - 2444
反应条件
trifluoroacetic acid
T=20°C; 0.75 h;
参考文献
Ley, Steven V.; Diez, Elena; Dixon, Darren J.; Guy, Richard T.; Michel, Patrick; Nattrass, Gillian L.; Sheppard, Tom D.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 24 p. 3608 - 3617
反应条件
ruthenium(IV) oxide; sodium periodate in tetrachloromethane; water; acetonitrile
12 h;
参考文献
O'Hagan, David; Zaidi, Naveed A.
Tetrahedron: Asymmetry, 1994 , vol. 5, # 6 p. 1111 - 1118
反应条件
1.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C
1.2: tetrahydrofuran / -78 - 20 °C
2.1: 85 percent / aq. TFA / 0.75 h / 20 °C
View Scheme
参考文献
Ley, Steven V.; Diez, Elena; Dixon, Darren J.; Guy, Richard T.; Michel, Patrick; Nattrass, Gillian L.; Sheppard, Tom D.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 24 p. 3608 - 3617
反应条件
1: 96 percent / LHMDS / tetrahydrofuran / 2 h / -78 - -30 °C
2: LHMDS / tetrahydrofuran / 2 h / -78 - 0 °C
3: 85 percent / aq. TFA / 0.17 h / 20 °C
View Scheme
参考文献
Diez, Elena; Dixon, Darren J.; Ley, Steven V.
Angewandte Chemie - International Edition, 2001 , vol. 40, # 15 p. 2906 - 2909
反应条件
1: 99.5 percent / H2 / Pd/C / tetrahydrofuran; methanol / 0.33 h / 20 °C / atmospheric pressure
2: 92 percent / HCl / H2O / 3 h / Heating
View Scheme
参考文献
Wang, Mei-Xiang; Deng, Gang; Wang, De-Xian; Zheng, Qi-Yu
Journal of Organic Chemistry, 2005 , vol. 70, # 7 p. 2439 - 2444
反应条件
hydrogenchloride
6 h; Heating;
参考文献
Jew, Sang-Sup; Kim, Hyun-Ah; Kim, Jeong-Hoon; Park, Hyeung-Geun
Heterocycles, 1997 , vol. 46, # 1 p. 65 - 70
反应条件
1: 1.) n-BuLi / 1.) Et2O, THF, 15 min, 2.) Et2O, THF, reflux, 1 h
3: KOH / methanol
4: 100 percent / NaIO4, RuO2 / CCl4; acetonitrile; H2O / 12 h
View Scheme
参考文献
O'Hagan, David; Zaidi, Naveed A.
Tetrahedron: Asymmetry, 1994 , vol. 5, # 6 p. 1111 - 1118
反应条件
2: KOH / methanol
3: 100 percent / NaIO4, RuO2 / CCl4; acetonitrile; H2O / 12 h
View Scheme
参考文献
O'Hagan, David; Zaidi, Naveed A.
Tetrahedron: Asymmetry, 1994 , vol. 5, # 6 p. 1111 - 1118
