(R)-2-羟基-2-甲基苯丙酸合成路线 （共 22 条）
反应条件
1: KOH / methanol
2: 100 percent / NaIO4, RuO2 / CCl4; acetonitrile; H2O / 12 h
View Scheme
参考文献
O'Hagan, David; Zaidi, Naveed A.
Tetrahedron: Asymmetry, 1994 , vol. 5, # 6 p. 1111 - 1118
反应条件
1: 77 percent / tetrahydrofuran / 4 h / Heating
2: 1.) n-BuLi / 1.) Et2O, THF, 15 min, 2.) Et2O, THF, reflux, 1 h
4: KOH / methanol
5: 100 percent / NaIO4, RuO2 / CCl4; acetonitrile; H2O / 12 h
View Scheme
参考文献
O'Hagan, David; Zaidi, Naveed A.
Tetrahedron: Asymmetry, 1994 , vol. 5, # 6 p. 1111 - 1118
反应条件
1: AD-mix-β <(DHQD)2PHAL> / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C
2: 87 percent / pyridine / CHCl3 / 24 h / Ambient temperature
3: 67 percent / LiBr / tetrahydrofuran / 40 h / 55 °C
4: 53 percent / Bu3SnH, AIBN / benzene / 0.33 h / Heating
5: 100 percent / 6N HCl / 6 h / Heating
View Scheme
参考文献
Jew, Sang-Sup; Kim, Hyun-Ah; Kim, Jeong-Hoon; Park, Hyeung-Geun
Heterocycles, 1997 , vol. 46, # 1 p. 65 - 70
反应条件
1: 61 percent / NaH / tetrahydrofuran / Heating
2: AD-mix-β <(DHQD)2PHAL> / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C
3: 87 percent / pyridine / CHCl3 / 24 h / Ambient temperature
4: 67 percent / LiBr / tetrahydrofuran / 40 h / 55 °C
5: 53 percent / Bu3SnH, AIBN / benzene / 0.33 h / Heating
6: 100 percent / 6N HCl / 6 h / Heating
View Scheme
参考文献
Jew, Sang-Sup; Kim, Hyun-Ah; Kim, Jeong-Hoon; Park, Hyeung-Geun
Heterocycles, 1997 , vol. 46, # 1 p. 65 - 70
反应条件
1: 100 percent / KOH / ethanol / 5 h / Ambient temperature
2: 61 percent / NaH / tetrahydrofuran / Heating
3: AD-mix-β <(DHQD)2PHAL> / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C
4: 87 percent / pyridine / CHCl3 / 24 h / Ambient temperature
5: 67 percent / LiBr / tetrahydrofuran / 40 h / 55 °C
6: 53 percent / Bu3SnH, AIBN / benzene / 0.33 h / Heating
7: 100 percent / 6N HCl / 6 h / Heating
View Scheme
参考文献
Jew, Sang-Sup; Kim, Hyun-Ah; Kim, Jeong-Hoon; Park, Hyeung-Geun
Heterocycles, 1997 , vol. 46, # 1 p. 65 - 70
反应条件
1: 53 percent / Bu3SnH, AIBN / benzene / 0.33 h / Heating
2: 100 percent / 6N HCl / 6 h / Heating
View Scheme
参考文献
Jew, Sang-Sup; Kim, Hyun-Ah; Kim, Jeong-Hoon; Park, Hyeung-Geun
Heterocycles, 1997 , vol. 46, # 1 p. 65 - 70
反应条件
1: 67 percent / LiBr / tetrahydrofuran / 40 h / 55 °C
2: 53 percent / Bu3SnH, AIBN / benzene / 0.33 h / Heating
3: 100 percent / 6N HCl / 6 h / Heating
View Scheme
参考文献
Jew, Sang-Sup; Kim, Hyun-Ah; Kim, Jeong-Hoon; Park, Hyeung-Geun
Heterocycles, 1997 , vol. 46, # 1 p. 65 - 70
反应条件
1: 87 percent / pyridine / CHCl3 / 24 h / Ambient temperature
2: 67 percent / LiBr / tetrahydrofuran / 40 h / 55 °C
3: 53 percent / Bu3SnH, AIBN / benzene / 0.33 h / Heating
4: 100 percent / 6N HCl / 6 h / Heating
View Scheme
参考文献
Jew, Sang-Sup; Kim, Hyun-Ah; Kim, Jeong-Hoon; Park, Hyeung-Geun
Heterocycles, 1997 , vol. 46, # 1 p. 65 - 70
反应条件
hydrogenchloride
8 h; Heating;
参考文献
Ludwig, Jerry W.; Newcomb, Martin; Bergbreiter, David E.
Tetrahedron Letters, 1986 , vol. 27, # 24 p. 2731 - 2734
反应条件
1: 97 percent / tetrahydrofuran; diethyl ether
View Scheme
参考文献
Frye, Stephen V.; Eliel, Ernest L.
Tetrahedron Letters, 1985 , vol. 26, # 33 p. 3907 - 3910
