6,8-二溴咪唑并[1,2-a]吡嗪合成路线 （共 18 条）
反应条件
in tetrahydrofuran; water T=20°C; 19 h; Reflux;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; JAUTELAT, Rolf; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard
Patent: WO2012/80236 A1, 2012 ;
Location in patent: Page/Page column 63 ;
WO 2012/080236 A1
反应条件
1: in water T=20°C; 2 h; Reflux; 2: With sodium hydrogencarbonate in water 0.25 h;
参考文献
Oncotherapy Science, Inc.
Patent: US2012/59162 A1, 2012 ;
Location in patent: Page/Page column 53-54 ;
反应条件
in water; isopropyl alcohol Reflux;
参考文献
Belanger, David B.; Curran, Patrick J.; Hruza, Alan; Voigt, Johannes; Meng, Zhaoyang; Mandal, Amit K.; Siddiqui, M. Arshad; Basso, Andrea D.; Gray, Kimberly
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5170 - 5174
反应条件
1: in N,N-dimethyl-formamide T=20°C; 12 h; 2: in ethanol 1 h; Heating / reflux;
参考文献
WO2008/5457 A2, ;
Page/Page column 184 ;
WO 2008/005457 A2
反应条件
in tetrahydrofuran; water T=20°C; 19 h; Reflux;
参考文献
WO2012/80234 A1, ;
Page/Page column 44-45 ;
WO 2012/080234 A1
反应条件
1: 96 percent / ammonia / ethanol / 5 h / 120 °C 2: H2 / Pd/C View Scheme
参考文献
Bonnet, Pierre A.; Michel, Alain; Laurent, Florence; Sablayrolles, Claire; Rechencq, Eliane; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3353 - 3358
反应条件
ammonia in ethanol T=120°C; 5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 18 p. 3353 - 3358
反应条件
N-chloro-succinimide in 1,2-dichloro-ethane; acetonitrile Reflux;
参考文献
Bouloc, Nathalie; Large, Jonathan M.; Kosmopoulou, Magda; Sun, Chongbo; Faisal, Amir; Matteucci, Mizio; Reynisson, Johannes; Brown, Nathan; Atrash, Butrus; Blagg, Julian; McDonald, Edward; Linardopoulos, Spiros; Bayliss, Richard; Bavetsias, Vassilios
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 20 p. 5988 - 5993
参考文献
Bonnet, Pierre A.; Michel, Alain; Laurent, Florence; Sablayrolles, Claire; Rechencq, Eliane; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3353 - 3358
反应条件
1: H2O / 12 h 2: H2 / Pd/C View Scheme
参考文献
Bonnet, Pierre A.; Michel, Alain; Laurent, Florence; Sablayrolles, Claire; Rechencq, Eliane; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3353 - 3358
