6,8-二溴咪唑并[1,2-a]吡嗪合成路线 （共 18 条）
参考文献
CELLULAR GENOMICS, INC.
Patent: WO2004/22562 A1, 2004 ;
Location in patent: Page 28 ;
WO 2004/022562 A1
参考文献
l'Universite de Montpellier I
Patent: US5028605 A1, 1991 ;
反应条件
1: H2O / 12 h
2: H2 / Pd/C
View Scheme
参考文献
Bonnet, Pierre A.; Michel, Alain; Laurent, Florence; Sablayrolles, Claire; Rechencq, Eliane; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3353 - 3358
参考文献
Belanger, David B.; Curran, Patrick J.; Hruza, Alan; Voigt, Johannes; Meng, Zhaoyang; Mandal, Amit K.; Siddiqui, M. Arshad; Basso, Andrea D.; Gray, Kimberly
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5170 - 5174
反应条件
1: methanol / 16 h / 23 °C / Inert atmosphere
2: N-iodo-succinimide / N,N-dimethyl-formamide / 6.5 h / 60 °C / Inert atmosphere
View Scheme
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; JAUTELAT, Rolf; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard
Patent: WO2012/80234 A1, 2012 ;
WO 2012/080234 A1
反应条件
N-bromosuccinmide in dichloromethane; acetonitrile
T=25°C; 48 h;
参考文献
SCHERING CORPORATION
Patent: US2004/63715 A1, 2004 ;
Location in patent: Page/Page column 46 ;
US 20040063715 A1
反应条件
N-bromosuccinmide in chloroform
参考文献
l'Universite de Montpellier I
Patent: US5028605 A1, 1991 ;
反应条件
1: methanol / 20 °C
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / N,N-dimethyl-formamide / 100 °C
View Scheme
参考文献
Zeng, Hongbo; Belanger, David B.; Curran, Patrick J.; Shipps Jr., Gerald W.; Miao, Hua; Bracken, Jack B.; Arshad Siddiqui; Malkowski, Michael; Wang, Yan
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5870 - 5875
