4-氨基异邻苯二甲酸二甲酯合成路线 （共 23 条）
反应条件
hydrogen; 10 palladium charcoal in methanol T=20°C;
参考文献
SoftCure Pharmaceuticals AB
Patent: WO2008/152142 A1, 2008 ;
Location in patent: Page/Page column 26 ;
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; 10 h;
参考文献
Sosic, Izidor; Barreteau, Helne; Simcic, Mihael; Sink, Roman; Cesar, Jozko; Zega, Anamarija; Grdadolnik, Simona Golic; Contreras-Martel, Carlos; Dessen, Andrea; Amoroso, Ana; Joris, Bernard; Blanot, Didier; Gobec, Stanislav
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 2880 - 2894
反应条件
boron trifluoride diethyl etherate in benzene T=80°C; 1 h;
参考文献
Padwa, Albert; Dimitroff, Martin; Waterson, Alex G.; Wu, Tianhua
Journal of Organic Chemistry, 1997 , vol. 62, # 12 p. 4088 - 4096
参考文献
US2002/193377 A1, ;
US 20020193377 A1
反应条件
1: thionyl chloride / 48 h / 20 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / methanol / 10 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 2880 - 2894
反应条件
1: copper(I) oxide; copper; potassium carbonate / 2-ethoxy-ethanol / 0.75 h / 130 °C / Microwave irradiation; Inert atmosphere 2: thionyl chloride / 48 h / 20 °C / Inert atmosphere 3: palladium 10 on activated carbon; hydrogen / methanol / 10 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 2880 - 2894
反应条件
1: alcohol; hydrochloric acid 2: HCl View Scheme
参考文献
Monatshefte fuer Chemie, , vol. 39, p. 394,395
参考文献
Monatshefte fuer Chemie, , vol. 41, p. 141
Monatshefte fuer Chemie, , vol. 39, p. 394,395
反应条件
2: sulfuric acid 3: aqueous-methanolic KOH-solution 5: 100 °C / im Rohr 6: bromine; KOH-solution 7: concentrated sulfuric acid View Scheme
参考文献
Monatshefte fuer Chemie, , vol. 31, p. 1297
