2-氟-5-甲基-4-硝基苯酚合成路线 （共 7 条）
反应条件
(i) aq. NaNO2, H2SO4, AcOH, (ii) aq. HNO3; Multistep reaction;
参考文献
Flaugh; Crowell; Clemens; Sawyer
Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69
反应条件
sulfuric acid; nitric acid; sodium nitrite in water; acetic acid
参考文献
Eli Lilly and Company
Patent: US4087444 A1, 1978 ;
反应条件
1: (i) aq. K2CO3, DMF, EtOH, (ii) /BRN= 969135/
2: H2 / Pd-C / ethanol
3: (i) aq. NaNO2, HCl, (ii) aq. HPF6, (iii) (heating)
4: Py*HCl / 150 - 220 °C
5: (i) aq. NaNO2, H2SO4, AcOH, (ii) aq. HNO3
View Scheme
参考文献
Flaugh; Crowell; Clemens; Sawyer
Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69
反应条件
1: H2 / Pd-C / ethanol
2: (i) aq. NaNO2, HCl, (ii) aq. HPF6, (iii) (heating)
3: Py*HCl / 150 - 220 °C
4: (i) aq. NaNO2, H2SO4, AcOH, (ii) aq. HNO3
View Scheme
参考文献
Flaugh; Crowell; Clemens; Sawyer
Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69
反应条件
1: Py*HCl / 150 - 220 °C
2: (i) aq. NaNO2, H2SO4, AcOH, (ii) aq. HNO3
View Scheme
参考文献
Flaugh; Crowell; Clemens; Sawyer
Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69
反应条件
1: (i) aq. NaNO2, HCl, (ii) aq. HPF6, (iii) (heating)
2: Py*HCl / 150 - 220 °C
3: (i) aq. NaNO2, H2SO4, AcOH, (ii) aq. HNO3
View Scheme
参考文献
Flaugh; Crowell; Clemens; Sawyer
Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69
反应条件
potassium carbonate in ethanol
参考文献
Flaugh; Crowell; Clemens; Sawyer
Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69
