3-硝基-4-甲氧基氯苄合成路线 (共 20 条)
反应条件
1: mercaptoacetic acid With sodium hydroxide in methanol 0.5 h; 2: 4-methoxy-3-nitrobenzyl chloride in methanol T=20°C; 4 h; Heating / reflux;
参考文献
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY
Patent: WO2006/104668 A2, 2006 ;
Location in patent: Page/Page column 32-33 ;
参考文献
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Patent: US2010/305059 A1, 2010 ;
反应条件
1: aqueous ethanol 2: aqueous hydrochloric acid 3: hydrogen chloride 4: palladium; ethyl acetate / Hydrogenation View Scheme
参考文献
Bersch
Archiv der Pharmazie (Weinheim, Germany), 1939 , vol. 277, p. 271,281
反应条件
1: potassium bromide; ethanol 2: aqueous sulfuric acid; acetic acid 3: palladium; methanol / Hydrogenation 4: aqueous sulfuric acid; sodium nitrite / Eintragen der Reaktionsloesung in heisse wss. Schwefelsaeure View Scheme
参考文献
Burger; Avakian
Journal of Organic Chemistry, 1940 , vol. 5, p. 606,608
反应条件
1: 60.1 percent / K2CO3 / dimethylsulfoxide / 1 h / 80 - 90 °C 2: 1.) Na / 2.) reflux, 1 h View Scheme
参考文献
Melik-Ogandzhanyan, R. G.; Khachatryan, V. E.; Israelyan, S. G.; Paronikyan, R. V.; Ter-Zakharyan, Yu. Z.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 3 p. 235 - 238
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 3 p. 302 - 304
反应条件
1: 60.1 percent / K2CO3 / dimethylsulfoxide / 1 h / 80 - 90 °C 2: 1.) Na / 2.) reflux, 1 h View Scheme
参考文献
Melik-Ogandzhanyan, R. G.; Khachatryan, V. E.; Israelyan, S. G.; Paronikyan, R. V.; Ter-Zakharyan, Yu. Z.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 3 p. 235 - 238
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 3 p. 302 - 304
反应条件
1: aqueous ethanol
2: aqueous hydrochloric acid
View Scheme
参考文献
Hromatka
Chemische Berichte, 1942 , vol. 75, p. 123,129
反应条件
1: potassium bromide; ethanol
2: aqueous sulfuric acid; acetic acid
3: palladium; methanol / Hydrogenation
View Scheme
参考文献
Hromatka
Chemische Berichte, 1942 , vol. 75, p. 123,129
参考文献
Burger; Avakian
Journal of Organic Chemistry, 1940 , vol. 5, p. 606,608
参考文献
Bersch
Archiv der Pharmazie (Weinheim, Germany), 1939 , vol. 277, p. 271,281