4-氯乙酰乙酸乙酯合成路线

参考文献

Aryx Therapeutics
Patent: US6316487 B1, 2001 ;

638-07-34-氯乙酰乙酸乙酯+

90-02-8水杨醛

1646-26-02-乙酰基苯并呋喃+

787-07-51,4-环己二酮-2,5-二甲酸二乙酯+

78917-44-93-(2-苯并呋喃基)-3-氧代丙酸乙酯

参考文献

Lamotte, Genevieve; Demerseman, Pierre; Royer, Rene
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638-07-34-氯乙酰乙酸乙酯+

53515-17-63-三氟甲基硫代苯甲酰胺

78743-00-72-{2-[3-(三氟甲基)苯基]-1,3-噻唑-4-基}乙酸乙酯

参考文献

Rooney; Randall; Streeter; Ziegler; Cragoe Jr.; Schwam; Michelson; Williams; Eichler; Duggan; Ulm; Noll
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 700 - 714

638-07-34-氯乙酰乙酸乙酯

78267-24-02-苯胺基-4-氯-5-甲酰基-3-噻吩羧酸乙酯

参考文献

Faull, Alan W.; Hull, Roy
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1078 - 1082

773837-37-9+

638-07-34-氯乙酰乙酸乙酯

141942-85-0R(-)-4-氰基-3-羟基丁酸乙酯+

312745-91-8(S)-(+)-4-氰-3-羟基丁酸乙酯

参考文献

Chen, Shao-Yun; Yang, Chen-Xi; Wu, Jian-Ping; Xu, Gang; Yang, Li-Rong
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 16 p. 3179 - 3190

1517-05-12-叠氮基乙醇+

638-07-34-氯乙酰乙酸乙酯

88150-45-2乙基(2-叠氮基乙氧基)乙酰乙酸酯

参考文献

SYNTA PHAMACEUTICALS CORP.
Patent: WO2005/25507 A2, 2005 ;
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638-07-34-氯乙酰乙酸乙酯

82156-58-9苯并呋喃-3-乙酸乙酯

参考文献

Kimura, Hitoshi; Sato, Hirotoshi; Tsuchiya, Chizuko; Chiba, Takuo; Kato, Tetsuzo
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 552 - 558

638-07-34-氯乙酰乙酸乙酯+

103-72-0硫代异氰酸苯酯

78267-15-9

参考文献

Bergman, Jan; Romero, Ivan
Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 5 p. 1215 - 1220

638-07-34-氯乙酰乙酸乙酯

88150-42-9络活喜

参考文献

Arrowsmith; Campbell; Cross; Stubbs; Burges; Gardiner; Blackburn
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1696 - 1702

638-07-34-氯乙酰乙酸乙酯

88150-62-3邻苯二甲酰基氨氯地平

参考文献

Arrowsmith; Campbell; Cross; Stubbs; Burges; Gardiner; Blackburn
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1696 - 1702