3-甲基-2-丁烯酸乙酯合成路线 （共 160 条）
反应条件
potassium tert-butylate 1.) THF, rt, 1 h, 2.) THF, reflux, 48 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Fujimoto, Tetsuya; Kodama, Yoh-Ichi; Yamamoto, Iwao; Kakehi, Akikazu
Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6627 - 6630
反应条件
1: HMPT / tetrahydrofuran 2: (i) aq. NaOH, EtOH, (ii) /BRN= 102415/ 3: (i) BF3-Et2O, (ii) aq. HCl View Scheme
参考文献
Smith,A.B. et al.
Tetrahedron Letters, 1975 , p. 4225 - 4228
反应条件
1: NBS, (PhCO)2O2 View Scheme
参考文献
Bittner,S. et al.
Phytochemistry (Elsevier), 1977 , vol. 16, p. 1143 - 1151
反应条件
potassium carbonate in N,N-dimethyl-formamide T=130°C; 8 h;
参考文献
Kawase, Yoshiyuki; Yamaguchi, Seiji; Horita, Hisanori; Takeno, Junko; Kameyama, Hideaki
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 4 p. 1153 - 1155
反应条件
1: ethyl 3,3-dimethyl-acrylate With copper(l) iodide; chloro-trimethyl-silane in tetrahydrofuran T=20°C; 0.25 h; 2: n-propyl-magnesium chloride in tetrahydrofuran; diethyl ether T=-15 - -10°C; Further stages.;
参考文献
Journal of the American Chemical Society, , vol. 124, # 44 p. 13097 - 13105
反应条件
2: m-chloroperbenzoic acid
3: 95 percent / Bf3.Et2O / 2 h / 35 °C
View Scheme
参考文献
Dehnel, Andre; Kanabus-Kaminska, Jolanta M.
Tetrahedron Letters, 1987 , vol. 28, # 34 p. 3907 - 3910
反应条件
1: AlCl3; CS2
2: aqueous NaOH
View Scheme
参考文献
Goo-on et al.
Journal of Organic Chemistry, 1954 , vol. 19, p. 305,309
反应条件
1: ethyl 3,3-dimethyl-acrylate With lithium diisopropyl amide in tetrahydrofuran; n-heptane
T=-78°C; 0.25 h; Inert atmosphere;
2: prenyl bromide in tetrahydrofuran; n-heptane
T=-78°C; 1 h; Inert atmosphere;
参考文献
Pepper, Henry P.; Tulip, Stephen J.; Nakano, Yuji; George, Jonathan H.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2564 - 2573
反应条件
in ethanol
24 h; Heating / reflux;
参考文献
Cociorva, Oana; Li, Bei; Szardenings, Katrin; Fukuda, Yasumichi; Nomura, Masahiro; Seto, Shigeki; Yumoto, Kazuhiro; Okada, Kyoko; Nakamura, Ayako
Patent: US2007/254866 A1, 2007 ;
Location in patent: Page/Page column 102 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=150°C; 15 h;
参考文献
Mannhold, Raimund; Cruciani, Gabriele; Weber, Horst; Lemoine, Horst; Derix, Andrea; Weichel, Claus; Clementi, Monica
Journal of Medicinal Chemistry, 1999 , vol. 42, # 6 p. 981 - 991
