3-甲基-2-丁烯酸乙酯合成路线 （共 160 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=130°C; 16 h;
参考文献
Kawase, Yoshiyuki; Yamaguchi, Seiji; Horita, Hisanori; Takeno, Junko; Kameyama, Hideaki
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 4 p. 1153 - 1155
反应条件
1.1: ammonia / ethanol / 16 h / -70 - 45 °C / 10343.2 Torr / Autoclave
1.2: 0.5 h / 0 °C / pH 2 / Inert atmosphere
2.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C
View Scheme
参考文献
AVILA THERAPEUTICS, INC.
Patent: US2011/230476 A1, 2011 ;
反应条件
1.1: CuI; TMSCl / tetrahydrofuran / 0.25 h / 20 °C
1.2: 95 percent / tetrahydrofuran; diethyl ether / -15 - -10 °C
2.1: 97 percent / NaOH / ethanol; H2O / 72 °C
View Scheme
参考文献
Barnes, David M.; Wittenberger, Steven J.; Zhang, Ji; Ji, Jianguo; Fickes, Michael G.; Fitzgerald, Michael A.; King, Steven A.; Morton, Howard E.; Plagge, Frederick A.; Preskill, Margo; Wagaw, Seble H.
Journal of the American Chemical Society, 2002 , vol. 124, # 44 p. 13097 - 13105
反应条件
Yield given. Multistep reaction;
参考文献
Motoyoshiya, Jiro; Miyajima, Masae; Hirakawa, Kiyoichi; Kakurai, Toshio
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1326 - 1327
反应条件
hydrazine hydrate in ethanol
T=80°C; 2 h;
参考文献
MERCK PATENT GMBH; YU, Henry; RICHARDSON, Thomas E.; FOGLESONG, Robert James; DESELM, Lizbeth Celeste; GOUTOPOULOS, Andreas
Patent: WO2013/6308 A2, 2013 ;
Location in patent: Page/Page column 109 ;
反应条件
AlCl3, aluminium chloride in dichloromethane
3 h; Inert atmosphereCoolingReflux;
参考文献
Sun, Chang-Liang; Fuerstner, Alois
Angewandte Chemie - International Edition, 2013 , vol. 52, # 49 p. 13071 - 13075
Angew. Chem., 2013 , vol. 125, # 49 p. 13309 - 13313,5
反应条件
peracetic acid in dichloromethane
T=60°C; 65 h; Inert atmosphere;
参考文献
Aho, Jatta E.; Piisola, Antti; Syam Krishnan; Pihko, Petri M.
European Journal of Organic Chemistry, 2011 , # 9 p. 1682 - 1694
反应条件
diethyl ether
T=0°C;
参考文献
Courtot
Bulletin de la Societe Chimique de France, 1906 , vol. <3>35, p. 984
Full Text Show Details
Blaise; Courtot
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1905 , vol. 140, p. 371
参考文献
Courtot
Bulletin de la Societe Chimique de France, 1906 , vol. <3>35, p. 984
Full Text Show Details
Blaise; Courtot
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1905 , vol. 140, p. 371
参考文献
Courtot
Bulletin de la Societe Chimique de France, 1906 , vol. <3>35, p. 984
Full Text Show Details
Blaise; Courtot
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1905 , vol. 140, p. 371
