3-甲基-2-丁烯酸乙酯合成路线 （共 160 条）
反应条件
diethylamine in tetrahydrofuran
T=20°C; Michael addition; P=12001200 Torr;
参考文献
Rulev, Alexander Yu.; Azad, Saleha; Kotsuki, Hiyoshizo; Maddaluno, Jacques
European Journal of Organic Chemistry, 2010 , # 33 p. 6423 - 6429
反应条件
1: petroleum ether; bromine
2: sodium ethylate; ethanol / Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge
3: 170 °C / Behandeln des Reaktionsprodukts mit wss. Natriumhydrogencarbonat-Loesung
View Scheme
参考文献
Scarpati
Annali di Chimica (Rome, Italy), 1955 , vol. 45, p. 1072
参考文献
Ilford Ltd.
Patent: US2704762 , 1953 ;
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Ilford Ltd.
Patent: US2688024 , 1952 ;
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Duffin; Kendall
Ind. chim. belge Sonderband 27.Congr. int. Chim. ind. Bruessel, 1954 , p. Bd. 3, S. 602
反应条件
amino-hydroxamic acid; sodium methylate in methanol
T=20°C; 18 h;
参考文献
SYNGENTA LIMITED
Patent: WO2007/96576 A1, 2007 ;
Location in patent: Example I3 ;
反应条件
acetic acid
1.) benzene, 50 deg C, 2 h;; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Akita, Munetaka; Yasuda, Hajime; Nakamura, Akira
Chemistry Letters, 1983 , p. 217 - 218
反应条件
2: 1.) sodium hydride / 1.) DME, 2.) DME, 70 deg C, 3 h
3: 1.) Mg, 2.) copper(I) chloride / 1.) ether, reflux, 30 min, 2.) reflux, 50 min
View Scheme
参考文献
Motoyoshiya, Jiro; Miyajima, Masae; Hirakawa, Kiyoichi; Kakurai, Toshio
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1326 - 1327
反应条件
sodium ethanolate in ethanol
T=20 - 50°C; 36 h;
参考文献
Ohsugi, Shin-Ichi; Nishide, Kiyoharu; Node, Manabu
Tetrahedron, 2003 , vol. 59, # 11 p. 1859 - 1871
反应条件
(i) nBu3SnH, Et2O, (ii) /BRN= 969135/, LiBr, 1,2-dimethoxy-ethane; Multistep reaction;
参考文献
Odic,Y.; Pereyre,M.
Journal of Organometallic Chemistry, 1973 , vol. 55, p. 273 - 294
反应条件
lithium hydride
T=187°C; 5 h; Yield given;
参考文献
Pickett, James E.; Van Dort, Paul C.
Tetrahedron Letters, 1992 , vol. 33, # 9 p. 1161 - 1164
反应条件
ethanol
unter Druck;
参考文献
Scheiber; Meisel
Chemische Berichte, 1915 , vol. 48, p. 261
