3-甲基-2-丁烯酸乙酯合成路线 （共 160 条）
反应条件
sodium methylate in N,N-dimethyl-formamide
参考文献
Andreeva, L. N.; Perlova, T. G.; Negrebetskii, V. V.; Dymova, S. F.; Koroleva, T. I.; et al.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 9 p. 1800 - 1801
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 9 p. 2017 - 2018
反应条件
in N,N-dimethyl-formamide
参考文献
Andreeva, L. N.; Perlova, T. G.; Negrebetskii, V. V.; Dymova, S. F.; Koroleva, T. I.; et al.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 9 p. 1800 - 1801
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 9 p. 2017 - 2018
反应条件
sodium methylate in N,N-dimethyl-formamide different ratio of sodium methoxide to the title compounds; Product distribution;
参考文献
Andreeva, L. N.; Perlova, T. G.; Negrebetskii, V. V.; Dymova, S. F.; Koroleva, T. I.; et al.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 9 p. 1800 - 1801
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 9 p. 2017 - 2018
反应条件
1.1: ammonia / ethanol / 16 h / -70 - 45 °C / 10343.2 Torr / Autoclave 1.2: 0.5 h / 0 °C / pH 2 / Inert atmosphere 2.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C 3.1: sodium ethanolate / toluene / 4 h / 80 °C 4.1: acetonitrile; water / 3 h / Reflux 5.1: bromine / tetrahydrofuran / 0.17 h / 20 °C 5.2: 2 h / 80 °C 6.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 2 h / 20 °C 7.1: caesium carbonate / palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / acetonitrile / 16 h / 85 °C / Inert atmosphere View Scheme
参考文献
AVILA THERAPEUTICS, INC.
Patent: US2011/230476 A1, 2011 ;
反应条件
diethyl ether; potassium ethanolate Loesen des Reaktionsprodukts in Wasser und Faellen mit Schwefelsaeure;
参考文献
Higginbotham; Lapworth
Journal of the Chemical Society, 1923 , vol. 123, p. 1329
反应条件
1: LDA-HMPA 2: PdCl2(MeCN)2 / CH2Cl2 / 5 h / 40 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 24, # 35 p. 3757 - 3760
反应条件
[MgBr](1+)*[n-Bu2SnBrIH](1-) in tetrahydrofuran T=20°C; 24 h;
参考文献
Shibata; Suwa; Ryu; Baba
Journal of Organic Chemistry, 2001 , vol. 66, # 25 p. 8690 - 8692
反应条件
ethanol beim Verseifen des Reaktionsprodukts mit siedender Natronlauge;
参考文献
Higginbotham; Lapworth
Journal of the Chemical Society, 1922 , vol. 121, p. 53
反应条件
und Verseifen des entstandenen Esters mit siedender Natronlauge;
参考文献
Higginbotham; Lapworth
Journal of the Chemical Society, 1922 , vol. 121, p. 53
反应条件
diethyl ether Zers. des Reaktionsprodukts mit Wasser;
参考文献
Blaise; Courtot
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1905 , vol. 140, p. 371
Full Text Show Details
Courtot
Bulletin de la Societe Chimique de France, vol. 35, p. 984
