反应条件
1: LDA / tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) -78 deg C, 1 h
2: LiAlH4 / diethyl ether / 3 h / 0 °C
3: imidazole / dimethylformamide / 1 h / Ambient temperature
4: 1.) 9-BBN, 2.) NaOH, H2O2 / 1.) reflux, 24 h
5: 91 percent / TfOH / cyclohexane; CH2Cl2 / 0.5 h / Ambient temperature
6: 98 percent / TBAF / tetrahydrofuran / 1 h / Ambient temperature
7: 88 percent / PDC / dimethylformamide / 2 h / Ambient temperature
8: 62 percent / Jones' reagent / acetone / 0.75 h / 0 °C
9: 38 percent / Hg(OAc)2, AcOOH, AcOH / 3 h / Ambient temperature
10: benzenesulfonyl chloride, pyridine / 15 h / 0 °C
11: 92 percent / H2 / 10percent Pd/C / tetrahydrofuran / 15 h
12: DCC, DMAP / CH2Cl2; dimethylformamide / 1 h / Ambient temperature
View Scheme
参考文献
Fleming, Ian; Lawrence, Nicholas J.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 17 p. 2679 - 2686
