(S)-1-N-苄氧羰基-2-氰基吡咯烷合成路线 （共 8 条）
反应条件
1: With p-toluenesulfonyl chloride in pyridine T=100°C; 3 h; 2: With hydrogenchloride in pyridine; water T=20°C;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: WO2005/121135 A1, 2005 ;
Location in patent: Page/Page column 241-242 ;
反应条件
ammonium hydroxide; iodine in tetrahydrofuran T=25°C;
参考文献
Shie, Jiun-Jie; Fang, Jim-Min
Journal of Organic Chemistry, 2007 , vol. 72, # 8 p. 3141 - 3144
反应条件
hydrogenchloride in pyridine
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1757602 A1, 2007 ;
反应条件
1.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0.33 h / -5 °C 1.2: 99 percent / NH4OH / tetrahydrofuran; H2O / 18 h / 20 °C 2.1: 83 percent / trifluoroacetic anhydride; triethylamine / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 85, # 2 p. 85 - 95
反应条件
1: 90 percent / aq. NaOH / 2 h / 5 °C 2: 96 percent / di-tert-butyl pyrocarbonate; ammonium hydrogencarbonate; pyridine / acetonitrile / 68 h 3: 96 percent / cyanuric chloride / dimethylformamide / 79 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 20 p. 4287 - 4295
反应条件
1: 90 percent / aq. NaOH / 2 h / 5 °C 2: 96 percent / di-tert-butyl pyrocarbonate; ammonium hydrogencarbonate; pyridine / acetonitrile / 68 h 3: 96 percent / cyanuric chloride / dimethylformamide / 79 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 20 p. 4287 - 4295
反应条件
diethylaluminium azide in xylene T=85°C; 9 h;
参考文献
Aureggi, Valentina; Sedelmeier, Gottfried
Angewandte Chemie - International Edition, 2007 , vol. 46, # 44 p. 8440 - 8444
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-10°C;
参考文献
Sureshbabu, Vommina V.; Naik, Shankar A.; Hemantha; Narendra; Das, Ushati; Guru Row, Tayur N.
Journal of Organic Chemistry, 2009 , vol. 74, # 15 p. 5260 - 5266
