1: hydrogen; sodium methylate / RuCl2((S)-DMSEGPHOS)((S)-DAIPEN) / methanol / 12 h / 20 °C / Inert atmosphere; Autoclave 2: hydrogen / Raney nickel / methanol / 12 h / 50 °C / Autoclave 3: potassium tert-butylate / dimethyl sulfoxide / 8 h / 60 °C View Scheme

hydrogenchloride in water; isopropyl alcohol T=70°C; Mannich Reaction; 13 h;