2-(6-溴吡啶-2-基)丙烷-2-醇合成路线 （共 4 条）
反应条件
1: 2,6-Dibromopyridine With n-butyllithium in tetrahydrofuran; hexane
T=-76 - -60°C;
2: acetone in tetrahydrofuran; hexane
T=20°C; Cooling with dry ice;
3: With ammonium chloride in tetrahydrofuran; hexane; water
参考文献
ELI LILLY AND COMPANY
Patent: WO2009/131814 A2, 2009 ;
Location in patent: Page/Page column 40 ;
WO 2009/131814 A2
反应条件
1: in tetrahydrofuran
T=0°C;
2: With water in tetrahydrofuran; ethyl acetate
参考文献
Britton, Thomas Charles; Dehlinger, Veronique; Fivush, Adam Michael; Hollinshead, Sean Patrick; Vokits, Benjamin Paul
Patent: US2009/253750 A1, 2009 ;
Location in patent: Page/Page column 10 ;
反应条件
hydrogenchloride in diethyl ether; water
参考文献
Sagara, Takeshi; Otsuki, Sachie; Sunami, Satoshi; Sakamoto, Toshihiro; Niiyama, Kenji; Yamamoto, Fuyuki; Yoshizumi, Takashi; Furuyama, Hidetomo; Goto, Yasuhiro; Bamba, Makoto; Takahashi, Keiji; Hirai, Hiroshi; Nishibata, Toshihide
Patent: US2007/254892 A1, 2007 ;
Location in patent: Page/Page column 51 ;
US 20070254892 A1
参考文献
Guay, Daniel; Girard, Mario; Hamel, Pierre; Laliberte, Sebastien; Friesen, Richard
Patent: US2003/114478 A1, 2003 ;
