(5-甲基噻吩-2-基)甲醇合成路线 （共 11 条）
反应条件
lithium in various solvent(s) Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Lozanova, A. V.; Moiseenkov, A. M.; Semenovskii, A. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 4 p. 619 - 623
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 4 p. 838 - 842
反应条件
lithium in various solvent(s) Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Lozanova, A. V.; Moiseenkov, A. M.; Semenovskii, A. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 4 p. 619 - 623
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 4 p. 838 - 842
反应条件
1: triphenylphosphine; tetrachloromethane / 1 h / |Reflux 2: sodium carbonate / acetonitrile View Scheme
参考文献
Boulos, John; Jakubik, Jan; Randakova, Alena; Avila, Cristina
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1363 - 1367
反应条件
triethylamine in diethyl ether 20 h; Ambient temperature;
参考文献
Trahanovsky, Walter S.; Miller, Deborah Louise; Wang, Yili
Journal of Organic Chemistry, 1997 , vol. 62, # 26 p. 8980 - 8986
反应条件
in neat (no solvent)
15 h; Irradiation;
参考文献
Krishnaswamy, N. R.; Kumar, Ch. Siva Sai Kamana; Prasanna, S.
Journal of Chemical Research, Miniprint, 1991 , # 7 p. 1801 - 1830
反应条件
sodium tetrahydroborate in ethanol; toluene
T=0 - 20°C;
参考文献
FAB PHARMA SAS; GERUSZ, Vincent; ESCAICH, Sonia; OXOBY, Mayalen; DENIS, Alexis
Patent: WO2011/61214 A1, 2011 ;
Location in patent: Page/Page column 95 ;
WO 2011/061214 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 4 h;
2: With water; potassium carbonate
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/65093 A2, 2007 ;
Location in patent: Page/Page column 76 ;
反应条件
perchloric acid; hydrogen sulfide in ethanol
Ambient temperatureOther acids (trichloroacetic acid, hydrochloric acid or hydrogen chloride).;
参考文献
Kharchenko, V. G.; Gubina, T. I.; Markushina, I. A.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, # 2 p. 343 - 347
Zhurnal Organicheskoi Khimii, 1982 , # 2 p. 394 - 399
反应条件
lithium aluminium tetrahydride in diethyl ether
Yield given;
参考文献
Lozanova, A. V.; Moiseenkov, A. M.; Semenovskii, A. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 4 p. 619 - 623
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 4 p. 838 - 842
反应条件
sodium hydroxide; sodium acetate
参考文献
Emerson; Patrick
Journal of Organic Chemistry, 1949 , vol. 14, p. 790,795
