5-溴-2-甲基苯并噻唑合成路线 （共 22 条）
反应条件
[Cp*Ru(CH3CN)3][SO3CF3]; lithium bromide T=100°C; 24 h; Inert atmosphere;
参考文献
Imazaki, Yusuke; Shirakawa, Eiji; Ueno, Ryota; Hayashi, Tamio
Journal of the American Chemical Society, 2012 , vol. 134, # 36 p. 14760 - 14763
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite T=0°C; 2 h;
参考文献
Molino, Bruce F.; Liu, Shuang; Guzzo, Peter R.; Beck, James P.
Patent: US2006/52378 A1, 2006 ;
Location in patent: Page/Page column 108 ;
US 20060052378 A1
反应条件
1-methyl-pyrrolidin-2-one; sodium hydride T=150°C; 1.5 h;
参考文献
Mylari; Larson; Beyer; Zembrowski; Aldinger; Dee; Siegel; Singleton
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 108 - 122
反应条件
1: 29 percent / P4S10 / benzene / 18 h / Heating 2: 49 percent / N-methylpyrrolidinone, NaH / 1.5 h / 150 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 108 - 122
反应条件
1: 90 percent / Na2S*9H2O, sulfur / ethanol / 2 h / Heating 2: 1.) glacial acetic acid, zinc / 1.) 60-70 deg C, 2.5 h, 2.) 60-70 deg C, 3 h View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 32, # 12 p. 1803 - 1811
反应条件
potassium hexacyanoferrate(III)
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 108 - 122
反应条件
pyridinium tribromide in water
参考文献
Heterocycles, , vol. 83, # 6 p. 1267 - 1274
反应条件
acetic acid; zinc 1.) 60-70 deg C, 2.5 h, 2.) 60-70 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Russian Journal of Organic Chemistry, , vol. 32, # 12 p. 1803 - 1811
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 24 h; Heating / reflux;
参考文献
PROLYSIS LTD
Patent: WO2007/107758 A1, 2007 ;
Location in patent: Page/Page column 96-97 ;
WO 2007/107758 A1
反应条件
potassium carbonate; palladium dichloride in water; N,N-dimethyl-formamide T=40 - 60°C; 3 h; other reactant: 6-bromo-2-methylbenzothiazole, other trimethylstannanes, other reagents: Pd(OAc)2, PdCl2(PPh3)2, PdCl2, other solvents: DMF, H2O, other reaction temperature and time; Product distribution;
参考文献
Bumagin; Nikitina; Beletskaya
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 12 p. 1803 - 1811
