6-溴-2,3-二氢-1H-吲哚盐酸盐合成路线 （共 5 条）
反应条件
borane-THF in tetrahydrofuran T=20°C; 18 h; Reflux;
参考文献
WO2010/128152 A1, ;
Page/Page column 106-107 ;
WO 2010/128152 A1
反应条件
sodium cyanoborohydride; acetic acid T=20°C;
参考文献
ACS Medicinal Chemistry Letters, , vol. 3, # 5 p. 373 - 377
反应条件
sulfuric acid; bromine; silver sulphate 0.5 h; Ambient temperatureother temperature;other time. Object of study: regioselectivity; Product distribution;
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, p. 349 - 352
反应条件
dimethylsulfide; tert-butylhypochlorite; sodium ethanolate; triethylamine 1.) -65 deg C, CH2Cl2, 1 h, 2.) -65 deg C --> RT, 2 h; Yield given. Multistep reaction;
参考文献
Kawase, Masami; Miyake, Yuko; Kikugawa, Yasuo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1401 - 1404
反应条件
1: With hydrogenchloride in 1,4-dioxane; ethanol T=90°C; 18 h; 2: With ammonium hydroxide in water
参考文献
AMGEN INC.
Patent: WO2009/158011 A1, 2009 ;
Location in patent: Page/Page column 28 ;
WO 2009/158011 A1
