1-苄基-4-苯基哌啶-4-醇合成路线 （共 30 条）
反应条件
in tetrahydrofuran T=-78 - 20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 20 p. 5435 - 5438
反应条件
1.1: potassium carbonate / acetonitrile / 16 h / 85 °C 2.1: magnesium / tetrahydrofuran / 1.17 h / Cooling with ice; Reflux 2.2: 3 h / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 17 p. 5238 - 5246
反应条件
in tetrahydrofuran T=0 - 20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 9 p. 3157 - 3162
反应条件
1: 70 percent / dimethylformamide / 70 °C 2: 77 percent / tetrahydrofuran / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 495 - 500
反应条件
1: 70 percent / dimethylformamide / 70 °C 2: 77 percent / tetrahydrofuran / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 495 - 500
反应条件
1: methanesulfonic acid / toluene / 4 h / Reflux 2: 1,2-dichloro-ethane / Cooling with ice; Reflux 3: methanol / 2.5 h / Reflux View Scheme
参考文献
Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Sakamuri, Sukumar; Enyedy, Istvan J; Kozikowski, Alan P; Zaman, Wahiduz A; Johnson, Kenneth M; Wang, Shaomeng
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 495 - 500
反应条件
1: 80 percent / H2SO4 / acetonitrile 2: H2 / Pd/C / ethanol View Scheme
参考文献
Giardina; Grugni, Mario; Rigolio, Roberto; Vassallo, Marco; Erhard, Karl; Farina, Carlo
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2307 - 2310
反应条件
1: 80 percent / H2SO4 / acetonitrile 2: 94 percent / aq. HCl / 72 h / Heating 3: 98 percent / 72 h / Heating 4: 98 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 5: 55 percent / H2 / Pd/C / ethanol View Scheme
参考文献
Giardina; Grugni, Mario; Rigolio, Roberto; Vassallo, Marco; Erhard, Karl; Farina, Carlo
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2307 - 2310
