3-(3,5-二叔丁基-4-羟基苯基)丙酸甲酯合成路线 (共 47 条)
反应条件
sulfuric acid 16 h; Reflux;
参考文献
Jones, Kevin M.; Hillringhaus, Tim; Klussmann, Martin
Tetrahedron Letters, 2013 , vol. 54, # 25 p. 3294 - 3297
反应条件
potassium tert-butylate 1) t-BuOH, 2) water, 116 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 38, # 8.2 p. 1677 - 1682
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 8 p. 1829 - 1835
反应条件
1: 2,6-di-tert-butyl-phenol With potassium hydroxide in water T=146°C; 4 - 8 h; 2: acrylic acid n-butyl ester; acrylic acid methyl ester in water T=135 - 141°C; 10 h; 3: With magnessium metasilicate in water Product distribution / selectivity;
参考文献
WO2007/94791 A1, ;
Page/Page column 10 ;
反应条件
sodium methylate T=20°C; 4 h;
参考文献
Volod'Kin; Zaikov; Evteeva
Russian Chemical Bulletin, 2012 , vol. 61, # 9 p. 1689 - 1693
Izv. Akad. Nauk, Ser. Khim., 2012 , # 9 p. 1673 - 1677,5
反应条件
in dimethyl sulfoxide T=115°C; 3 h;
参考文献
Volod'Kin; Zaikov; Evteeva
Russian Chemical Bulletin, 2012 , vol. 61, # 9 p. 1689 - 1693
Izv. Akad. Nauk, Ser. Khim., 2012 , # 9 p. 1673 - 1677,5
反应条件
1: 2,6-di-tert-butyl-phenol With potassium hydroxide in water T=146°C; 2 - 4 h; 2: acrylic acid n-butyl ester; acrylic acid methyl ester in water T=135 - 141°C; 2.25 h; Product distribution / selectivity;
参考文献
US2006/183935 A1, ;
Page/Page column 4 ;
反应条件
sodium hydroxide T=116°C;
参考文献
Russian Chemical Bulletin, , vol. 51, # 12 p. 2189 - 2195
反应条件
potassium tert-butylate; silver nitrate; acrylonitrile 1.) DMSO, RT, 30 min, 2.) DMSO, RT; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Chemical Research, Synopses, , # 9 p. 366 - 367
参考文献
Pharmaceutical Chemistry Journal, , vol. 34, # 5 p. 273 - 275
反应条件
potassium hydroxide in dimethyl sulfoxide T=160°C; 5 h; various bases, time, solvents; Product distribution;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 20, p. 1732 - 1737
Zhurnal Organicheskoi Khimii, , vol. 20, # 9 p. 1899 - 1905