(5-氨基-1H-1,2,4-噻唑-3-基)甲醇合成路线 （共 3 条）
反应条件
in water T=25 - 108°C; 22.1 h;
参考文献
COCRYSTAL DISCOVERY, INC.; LEE, Sam, Sk; SHEN, Wang; ZHENG, Xiaoliang; JACOBSON, Irina, C.
Patent: WO2012/83105 A1, 2012 ;
Location in patent: Page/Page column 101 ;
WO 2012/083105 A1
反应条件
1: acetic acid / ethanol / |Inert atmosphere
2: [bis(acetoxy)iodo]benzene; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / dichloromethane / 7 h / 33.5 °C / |Inert atmosphere; |Large scale
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参考文献
Camp, David; Matthews, Chris F.; Neville, Sean T.; Rouns, Michael; Scott, Robert W.; Truong, Yen
Organic Process Research and Development, 2006 , vol. 10, # 4 p. 814 - 821
反应条件
in ethanol; acetic acid
20 h; Heating / reflux;
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2005/176701 A1, 2005 ;
Location in patent: Page/Page column 144 ;
US 20050176701 A1
