1: 2-methoxy-pyrazine With 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran T=-78°C; 0.5 h; Inert atmosphere; 2: formic acid ethyl ester in tetrahydrofuran T=-78°C; 0.5 h; Inert atmosphere;

1: 2-iodo-3-methoxypyrazine With isopropylmagnesium chloride in tetrahydrofuran T=0°C; Metallation; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=0°C; Formylation; 2 h;