1-苄基-1H-吡唑-4-甲醛合成路线 （共 4 条）
反应条件
1: With Dess-Martin periodane in dichloromethane T=20°C; 1.5 h; 2: With water; sodium hydrogencarbonate; sodium thiosulfate in dichloromethane T=20°C; 0.5 h;
参考文献
SEPRACOR INC.
Patent: US2008/4327 A1, 2008 ;
Location in patent: Page/Page column 76 ;
反应条件
1: N-Bn-4-iodo-1H-pyrazole With isopropylmagnesium chloride in tetrahydrofuran; diethyl ether T=0°C; 1 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; diethyl ether T=20°C; 1 h;
参考文献
Usami, Yoshihide; Watanabe, Ryo; Fujino, Yuiko; Shibano, Makio; Ishida, Chihiro; Yoneyama, Hiroki; Harusawa, Shinya; Ichikawa, Hayato
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 12 p. 1550 - 1560
反应条件
trichlorophosphate T=90 - 100°C; 3 h;
参考文献
Echevarria, Aurea; Elguero, Jose; Meutermans, Wim
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 957 - 960
反应条件
1-nitroethane; sodium acetate in acetic acid 5 h; Heating;
参考文献
Heinisch, Gottfried; Holzer, Wolfgang
Heterocycles, 1988 , vol. 27, # 10 p. 2443 - 2458
