1-(4-氯苯基)吡唑-4-甲醛合成路线 （共 6 条）
反应条件
trichlorophosphate T=70°C; Vilsmeier-Haack reaction; 12 h;
参考文献
Menegatti, Ricardo; Cunha, Anna C.; Ferreira, Vitor F.; Perreira, Edna F. R.; El-Nabawi, Ahmed; Eldefrawi, Amira T.; Albuquerque, Edson X.; Neves, Gilda; Rates, Stela M. K.; Fraga, Carlos A. M.; Barreiro, Eliezer J.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4807 - 4813
反应条件
trifluoroacetic acid 12 h;
参考文献
Dwivedi; De Boni; Goncalves; Mairink; Menegatti; Fonseca; Zilio
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2013 , vol. 105, p. 483 - 487
反应条件
trichlorophosphate T=90°C; Vilsmeier-Haack reaction; 3 h;
参考文献
Chornous; Bratenko; Vovk
Chemistry of Heterocyclic Compounds, 2006 , vol. 42, # 9 p. 1242 - 1243
反应条件
1: 86 percent / HCl / ethanol / 1 h / Heating 2: 78 percent / POCl3 / 12 h / 70 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 22 p. 4807 - 4813
反应条件
trifluoroacetic acid Duff reaction;
参考文献
Magnetic Resonance in Chemistry, , vol. 49, # 8 p. 537 - 542
反应条件
Jone's reagent in acetone T=0 - 20°C; 1 h;
参考文献
PROTEOSTASIS THERAPEUTICS, INC.
Patent: US2012/316193 A1, 2012 ;
Location in patent: Page/Page column 44 ;
