sodium bromide in 1-methyl-pyrrolidin-2-one T=100°C; Cyclization; isomerization; P=760 Torr; 24 h;

sodium bromide in 1-methyl-pyrrolidin-2-one T=100°C; Isomerization; 3 h;

ammonia; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in water; acetonitrile T=70°C;

sodium azide; Agrobacterium radiobacter halohydrin dehalogenase pH=7.5; 48 h; aq. potassium phosphate bufferEnzymatic reaction; optical yield given as percent ee;

potassium chloride; sodium perchlorate T=25°C; different pH 2-14; Rate constantMechanism;

sodium azide; Agrobacterium radiobacter halohydrin dehalogenase pH=7.5; 48 h; aq. potassium phosphate bufferEnzymatic reaction; optical yield given as percent ee;

N-bromosuccinmide; ammonium cerium(IV) nitrate in water; acetonitrile T=20°C; 8 h;

1.1: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 1,4-dioxane / 4 h / 90 °C 2.1: sodium hydride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere 2.2: 17 h / 20 °C / Cooling with ice 3.1: hydrogen bromide; acetic acid; phenol / 12 h / 75 °C / sealed tube; microwave irradiation 4.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 1 h 5.1: NH2NH2•xH2O / FeCl3·6H2O / methanol / 5 h / Reflux 5.2: 7 h / Reflux View Scheme

potassium chloride in 1,4-dioxane-d8; water-d2 0.5 h; Ambient temperaturepD 7.7; Rate constantMechanism;

aluminum oxide; sodium tetrahydroborate; palladium dichloride in hexane; water T=60°C; 3 h;