4-[[1-[(1,1-二甲基乙氧基)羰基]-1H-咪唑-4-基]羰基]-1-哌啶羧酸叔丁酯合成路线 （共 3 条）
反应条件
oxalyl dichloride; dimethyl sulfoxide in dichloromethane
T=-60°C; 0.75 h;
参考文献
Kitbunnadaj, Ruengwit; Zuiderveld, Obbe P.; De Esch, Iwan J. P.; Vollinga, Roeland C.; Bakker, Remko; Lutz, Martin; Spek, Anthony L.; Cavoy, Emile; Deltent, Marie-France; Menge, Wiro M. P. B.; Timmerman, Henk; Leurs, Rob
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5445 - 5457
反应条件
1.1: EtMgBr / CH2Cl2; tetrahydrofuran / 0.75 h / 20 °C
1.2: 89 percent / CH2Cl2; tetrahydrofuran / 16 h
2.1: 85 percent / H2; aq. HCl / Pd/C; Rh/C / methanol / 48 h / 76000 Torr
3.1: Et3N / methanol / 24 h / 20 °C
4.1: 95 percent / (COCl)2; DMSO / CH2Cl2 / 0.75 h / -60 °C
View Scheme
参考文献
Kitbunnadaj, Ruengwit; Zuiderveld, Obbe P.; De Esch, Iwan J. P.; Vollinga, Roeland C.; Bakker, Remko; Lutz, Martin; Spek, Anthony L.; Cavoy, Emile; Deltent, Marie-France; Menge, Wiro M. P. B.; Timmerman, Henk; Leurs, Rob
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5445 - 5457
反应条件
1: 85 percent / H2; aq. HCl / Pd/C; Rh/C / methanol / 48 h / 76000 Torr
2: Et3N / methanol / 24 h / 20 °C
3: 95 percent / (COCl)2; DMSO / CH2Cl2 / 0.75 h / -60 °C
View Scheme
参考文献
Kitbunnadaj, Ruengwit; Zuiderveld, Obbe P.; De Esch, Iwan J. P.; Vollinga, Roeland C.; Bakker, Remko; Lutz, Martin; Spek, Anthony L.; Cavoy, Emile; Deltent, Marie-France; Menge, Wiro M. P. B.; Timmerman, Henk; Leurs, Rob
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5445 - 5457
