反-4-苄氧基-3-甲氧基-β-硝基苯乙烯合成路线 （共 20 条）
反应条件
palladium on activated charcoal; ethanol Hydrogenation.unter Zusatz von wenig konz.wss.HCl;
参考文献
Kulikov, S. V.; Samartsev, M. A.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 2.2 p. 280 - 288
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 2 p. 348 - 358
反应条件
sodium tetrahydroborate in 1,4-dioxane; ethanol T=30°C; 0.75 h;
参考文献
Bhattacharjya, Anup; Mukhopadhyay, Ranjan; Pakrashi, Satyesh C.
Synthesis, 1985 , # 9 p. 886 - 887
反应条件
methanol; amberlyst-15 in toluene T=110°C;
参考文献
Petchmanee, Thaninee; Ploypradith, Poonsakdi; Ruchirawat, Somsak
Journal of Organic Chemistry, 2006 , vol. 71, # 7 p. 2892 - 2895
反应条件
iodine in 1,2-bis-(2-hydroxyethoxy)-ethane T=120°C; 3 h;
参考文献
Anuradha; Srinivas, Pullela V.; Ranga Rao; Manjulatha; Purohit, Muralidhar G.; Madhusudana Rao
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 20 p. 6820 - 6826
反应条件
nitric acid; nitrogen(IV) oxide in acetic acid
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1965 , p. 1417 - 1423
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 2.5 h; Reflux; 2: With water in tetrahydrofuran T=0°C; 3: With hydrogenchloride in diethyl ether
参考文献
Qian, Wangke; Lu, Weijian; Sun, Haifeng; Li, Zeng; Zhu, Liyuan; Zhao, Rui; Zhang, Lei; Zhou, Shengbin; Zhou, Yu; Jiang, Hualiang; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 15 p. 4862 - 4871
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / |Reflux 2: ethanol / 14 h / |Reflux 3: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 4: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 5: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 6: water; sodium hydroxide / ethanol / 3 h / 20 °C 7: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 8: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C 9: hydrogenchloride / water; ethanol / 2 h / |Reflux View Scheme
参考文献
Sun, Haifeng; Zhu, Liyuan; Yang, Huicui; Qian, Wangke; Guo, Lin; Zhou, Shengbin; Gao, Bo; Li, Zeng; Zhou, Yu; Jiang, Hualiang; Chen, Kaixian; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 856 - 868
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux 2.1: triethylamine / dichloromethane / 3 h / 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux 4.1: sodium hydroxide / chloroform / 0 - 20 °C 5.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere 5.2: 20 °C / Inert atmosphere; Cooling with ice 6.1: palladium 10 on activated carbon; hydrogen; acetic acid / methanol / 16 h 7.1: berberine bridge enzyme; tris(hydroxymethyl)methylamine hydrochloride; magnesium chloride / toluene / 24 h / 40 °C / pH 9 / Darkness; Enzymatic reaction View Scheme
参考文献
Schrittwieser, Joerg H.; Resch, Verena; Wallner, Silvia; Lienhart, Wolf-Dieter; Sattler, Johann H.; Resch, Jasmin; MacHeroux, Peter; Kroutil, Wolfgang
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6703 - 6714
反应条件
1: 55 percent / lithium aluminum hydride / diethyl ether; tetrahydrofuran / 1.) reflux, 2 h, 2.) room temperature, overnight 2: formic acid / 48 h / 50 °C 3: 88 percent / ammonium sulfate / toluene / 48 h / Heating 4: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h 5: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature 6: K2CO3 / acetone / 14 h / Heating 7: lithium aluminum hydride / tetrahydrofuran / Heating 8: 0.026 g / hydrogen / 10percent Pd/C / acetic acid; methanol / 6 h / 2585.7 Torr View Scheme
参考文献
Meyers, A. I.; Guiles, Joseph
Heterocycles, 1989 , vol. 28, # 1 p. 295 - 301
反应条件
hydrogenchloride; hydrogen; iron(III) chloride; platinum in water 4 h;
参考文献
Kulikov, S. V.; Samartsev, M. A.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 2.2 p. 280 - 288
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 2 p. 348 - 358
