[4-(4,6-二氯嘧啶基-2-磺酰基)苯基L]甲胺环丙羧酸合成路线 （共 2 条）
反应条件
in water; ethyl acetate; tert-butyl alcohol T=90°C; 1 h;
参考文献
MERCK and CO., INC.
Patent: WO2007/87245 A2, 2007 ;
Location in patent: Page/Page column 27 ;
WO 2007/087245 A2
Title/Abstract Full Text Show Details
MERCK and CO., INC.; VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/87246 A2, 2007 ;
Location in patent: Page/Page column 27 ;
WO 2007/087246 A2
反应条件
1.1: thionyl chloride / 2 h / 80 °C / |Inert atmosphere 1.2: 0 - 20 °C / |Inert atmosphere 2.1: potassium carbonate / tert-butyl alcohol / 4 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 33 p. 8551 - 8556
Angew. Chem., , vol. 125, # 33 p. 8713 - 8718,6
