N-(4-磺酰基苯基)甲胺环丙羧酸合成路线 （共 3 条）
反应条件
pyridine in tetrahydrofuran T=-5 - 20°C; Inert atmosphere;
参考文献
ABRAXIS BIOSCIENCE, LLC; TAO, Chunlin; WANG, Qinwei; NALLAN, Laxman; POLAT, Tulay; HO, David; DESAI, Neil, P.
Patent: WO2010/144550 A1, 2010 ;
Location in patent: Page/Page column 61 ;
WO 2010/144550 A1
反应条件
1: cyclopropanecarboxylic acid With thionyl chloride T=80°C; 2 h; Inert atmosphere; 2: 4-aminophenylmercaptan in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Li, Zhengqiu; Hao, Piliang; Li, Lin; Tan, Chelsea Y. J.; Cheng, Xiamin; Chen, Grace Y. J.; Sze, Siu Kwan; Shen, Han-Ming; Yao, Shao Q.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 33 p. 8551 - 8556
Angew. Chem., 2013 , vol. 125, # 33 p. 8713 - 8718,6
反应条件
in water; ethyl acetate; tert-butyl alcohol T=90°C; 1 h;
参考文献
MERCK and CO., INC.
Patent: WO2007/87245 A2, 2007 ;
Location in patent: Page/Page column 27 ;
WO 2007/087245 A2
Title/Abstract Full Text Show Details
MERCK and CO., INC.; VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/87246 A2, 2007 ;
Location in patent: Page/Page column 27 ;
WO 2007/087246 A2
