2-(Boc-氨基)异烟酸甲酯合成路线 （共 6 条）
反应条件
4-(N,N-dimethlyamino)pyridine in acetone; tert-butyl alcohol T=20°C; 15 h;
参考文献
Poon, Jia-Fei; Alao, John Patrick; Sunnerhagen, Per; Diner, Peter
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 27 p. 4526 - 4536
反应条件
1: methanol; 2-aminopyridine-4-carboxylic acid With sulfuric acid T=75°C; 18 h; 2: di-tert-butyl dicarbonate in tert-butyl alcohol T=60°C; 19 h;
参考文献
Kuramochi, Takahiro; Kakefuda, Akio; Yamada, Hiroyoshi; Tsukamoto, Issei; Taguchi, Taku; Sakamoto, Shuichi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 12 p. 4022 - 4036
反应条件
1.1: ammonia / H2O / 22 h / 240 °C 2.1: H2SO4 / 18 h / 75 °C 2.2: 10.4 g / 2-methyl-propan-2-ol / 19 h / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 12 p. 4022 - 4036
反应条件
1: sodium tetrahydroborate; calcium chloride / ethanol / 7 h / 20 °C 2: Dess-Martin periodane / dichloromethane / 15 h View Scheme
参考文献
Poon, Jia-Fei; Alao, John Patrick; Sunnerhagen, Per; Diner, Peter
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 27 p. 4526 - 4536
反应条件
1: 90 percent / CaCl2; NaBH4 / ethanol / 4 h / 20 °C 2: triethylamine / tetrahydrofuran / 0 - 20 °C 3: 11.24 g / dimethylformamide / 50 °C 4: 100 percent / H2NNH2*H2O / methanol; CHCl3 / 24 h / 20 °C View Scheme
参考文献
Kuramochi, Takahiro; Kakefuda, Akio; Yamada, Hiroyoshi; Tsukamoto, Issei; Taguchi, Taku; Sakamoto, Shuichi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 12 p. 4022 - 4036
反应条件
sodium tetrahydroborate; calcium chloride in ethanol T=20°C; 4 h;
参考文献
Kuramochi, Takahiro; Kakefuda, Akio; Yamada, Hiroyoshi; Tsukamoto, Issei; Taguchi, Taku; Sakamoto, Shuichi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 12 p. 4022 - 4036
