2-(Boc-氨基)-4-(氨甲基)吡啶合成路线 （共 7 条）
反应条件
sodium tetrahydroborate; water; palladium 10 on activated carbon in tetrahydrofuran T=20°C; 4 h;
参考文献
ASTRAZENECA AB
Patent: WO2005/58826 A1, 2005 ;
Location in patent: Page/Page column 99-100 ;
WO 2005/058826 A1
反应条件
hydrazine hydrate in methanol; chloroform T=20°C; 24 h;
参考文献
Kuramochi, Takahiro; Kakefuda, Akio; Yamada, Hiroyoshi; Tsukamoto, Issei; Taguchi, Taku; Sakamoto, Shuichi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 12 p. 4022 - 4036
反应条件
1: triethylamine / tetrahydrofuran / 0 - 20 °C 2: 11.24 g / dimethylformamide / 50 °C 3: 100 percent / H2NNH2*H2O / methanol; CHCl3 / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 12 p. 4022 - 4036
反应条件
1: 90 percent / CaCl2; NaBH4 / ethanol / 4 h / 20 °C 2: triethylamine / tetrahydrofuran / 0 - 20 °C 3: 11.24 g / dimethylformamide / 50 °C 4: 100 percent / H2NNH2*H2O / methanol; CHCl3 / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 12 p. 4022 - 4036
反应条件
1: 11.24 g / dimethylformamide / 50 °C 2: 100 percent / H2NNH2*H2O / methanol; CHCl3 / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 12 p. 4022 - 4036
反应条件
1.1: ammonia / H2O / 22 h / 240 °C 2.1: H2SO4 / 18 h / 75 °C 2.2: 10.4 g / 2-methyl-propan-2-ol / 19 h / 60 °C 3.1: 90 percent / CaCl2; NaBH4 / ethanol / 4 h / 20 °C 4.1: triethylamine / tetrahydrofuran / 0 - 20 °C 5.1: 11.24 g / dimethylformamide / 50 °C 6.1: 100 percent / H2NNH2*H2O / methanol; CHCl3 / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 12 p. 4022 - 4036
反应条件
1.1: H2SO4 / 18 h / 75 °C 1.2: 10.4 g / 2-methyl-propan-2-ol / 19 h / 60 °C 2.1: 90 percent / CaCl2; NaBH4 / ethanol / 4 h / 20 °C 3.1: triethylamine / tetrahydrofuran / 0 - 20 °C 4.1: 11.24 g / dimethylformamide / 50 °C 5.1: 100 percent / H2NNH2*H2O / methanol; CHCl3 / 24 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 12 p. 4022 - 4036
