6,7-二氢-4H-噻吩并[3,2-c]吡喃-4-甲胺合成路线 （共 2 条）
反应条件
1: 2-[2-(tert-butyldimethylsilyloxy)ethyl]thiophene With n-butyllithium in diethyl ether; hexane
T=-78°C; 3 h;
2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in diethyl ether; hexane
T=-78 - 22°C; 3 h;
3: 2-aminoacetaldehyde dimethyl acetal With trifluorormethanesulfonic acid
T=0 - 20°C;
参考文献
SUNOVION PHARMACEUTICALS, INC.; PSYCHOGENICS INC.; SHAO, Liming; CAMPBELL, John, Emerson; HEWITT, Michael, Charles; CAMPBELL, Una; HANANIA, Taleen, G.
Patent: WO2011/69063 A2, 2011 ;
Location in patent: Page/Page column 74 ;
反应条件
1.1: 1H-imidazole / dichloromethane / 1 h / 22 °C
2.1: n-butyllithium / hexane; diethyl ether / 3 h / -78 °C
2.2: 3 h / -78 - 22 °C
2.3: 0 - 20 °C
View Scheme
参考文献
SUNOVION PHARMACEUTICALS, INC.; PSYCHOGENICS INC.; SHAO, Liming; CAMPBELL, John, Emerson; HEWITT, Michael, Charles; CAMPBELL, Una; HANANIA, Taleen, G.
Patent: WO2011/69063 A2, 2011 ;
