1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane T=115°C; 18 h;

in trifluoroacetic acid 28 h; Heating;

sodium chlorite; sodium dihydrogenphosphate; aminosulfonic acid; sodium sulfite in 1,4-dioxane 0.25 h;

1: 1,4-diaza-bicyclo[2.2.2]octane / 16 h / Reflux 2: sulfuric acid / acetic acid / 1 h / 100 °C 3: sodium hypochlorite; sodium hydroxide / methanol / 24 h / 25 °C 4: hydrogen / methanol / 20 h / 80 °C / 22502.3 Torr 5: water; potassium hydroxide / methanol / 24 h / Reflux 6: bromine / water / 2 h / 0 - 5 °C View Scheme

1: 1,4-diaza-bicyclo[2.2.2]octane / 16 h / Reflux 2: sulfuric acid / acetic acid / 1 h / 100 °C 3: sodium hypochlorite; sodium hydroxide / methanol / 24 h / 25 °C View Scheme

1: 1,4-diaza-bicyclo[2.2.2]octane / 16 h / Reflux 2: sulfuric acid / acetic acid / 1 h / 100 °C 3: sodium hypochlorite; sodium hydroxide / methanol / 24 h / 25 °C 4: hydrogen / methanol / 20 h / 80 °C / 22502.3 Torr 5: water; potassium hydroxide / methanol / 24 h / Reflux 6: ethanol; water / 1 h / 20 °C 7: acetic acid / 2 - 4 h / 100 °C 8: sodium tetrahydroborate / dichloromethane; water; isopropyl alcohol / 16 h / 20 - 25 °C View Scheme