2-溴-N-[4-(2-氟苯甲酰)-1,3-二甲基-1H-吡唑-5-基]-乙酰胺合成路线 （共 7 条）
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 15 min, 2.) THF, from -70 deg C to RT, 18 h
2: 43 percent / Jones reagent / CH2Cl2 / 0.33 h / 0 °C
3: 10.0 g / 3 N aq. HCl / 18 h / Heating
View Scheme
参考文献
Wise; Butler; DeWald; Lustgarten; Coughenour; Downs; Heffner; Pugsley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1628 - 1637
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 15 min, 2.) THF, from -70 deg C to RT, 18 h
2: 43 percent / Jones reagent / CH2Cl2 / 0.33 h / 0 °C
3: 10.0 g / 3 N aq. HCl / 18 h / Heating
View Scheme
参考文献
Wise; Butler; DeWald; Lustgarten; Coughenour; Downs; Heffner; Pugsley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1628 - 1637
反应条件
1: 43 percent / Jones reagent / CH2Cl2 / 0.33 h / 0 °C
2: 10.0 g / 3 N aq. HCl / 18 h / Heating
View Scheme
参考文献
Wise; Butler; DeWald; Lustgarten; Coughenour; Downs; Heffner; Pugsley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1628 - 1637
反应条件
1: 1.) AlCl3 / 1.) s-tetrachloroethane, 10 deg C, 30 min, 2.) s-tetrachloroethane, a) 10 deg C, 1 h, b) reflux, 4 h
2: 85 percent / aq. H2SO4 / 4 h / 75 °C
View Scheme
参考文献
Wise; Butler; DeWald; Lustgarten; Coughenour; Downs; Heffner; Pugsley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1628 - 1637
反应条件
1: 10.0 g / 3 N aq. HCl / 18 h / Heating
View Scheme
参考文献
Wise; Butler; DeWald; Lustgarten; Coughenour; Downs; Heffner; Pugsley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1628 - 1637
反应条件
1: 85 percent / aq. H2SO4 / 4 h / 75 °C
View Scheme
参考文献
Wise; Butler; DeWald; Lustgarten; Coughenour; Downs; Heffner; Pugsley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1628 - 1637
参考文献
Wise; Butler; DeWald; Lustgarten; Coughenour; Downs; Heffner; Pugsley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1628 - 1637
