反应条件
1: 1.) LDA, HMPA / 1.) THF, -78 deg C 2: Al(Hg) / tetrahydrofuran; H2O 3: 94 percent / pyridine / tetrahydrofuran / Heating 4: 1.) n-BuLi, TMEDA, 2.) DMF 5: 1.) Et2O, pentane, -78 deg C, 2.) DMAP, 20 deg C 6: 56 percent / LICA / tetrahydrofuran / -78 deg C to 20 deg C 7: 94 percent / K2CO3 / acetone 8: 1.) LICA / 1.) THF, 0 deg C, 2.) 0 deg C 9: 1.) KOH, 2.) aq. oxalic acid, silicagel / 1.) MeOH, 2.) CH2Cl2, 20 deg C 10: 1.) O3, 2.) CF3COOH / 1.) MeOH, -78 deg C, 2.) CHCl3, H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 40 p. 4629 - 4632
