1.1: 4-(N,N-dimethlyamino)pyridine; 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 h / Reflux 2.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / methanol / 23 h / 760.05 Torr 3.1: acetonitrile / 0.25 h / 20 °C 3.2: 7 h / 20 °C / Reflux View Scheme

hydrogen bromide; acetic acid

1.1: 4-(N,N-dimethlyamino)pyridine; 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 h / Reflux 2.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / methanol / 23 h / 760.05 Torr 3.1: acetonitrile / 0.25 h / 20 °C 3.2: 7 h / 20 °C / Reflux 4.1: hydrogen / palladium 10 on activated carbon / methanol / 42 h / 2362.74 Torr View Scheme

ammonia in diethyl ether; chloroform T=-60 - -45°C;

ammonium hydroxide in water 5 h; Ambient temperature;

tetrahydrofuran T=-35 - -20°C; anschliessendes Einleiten von NH3;

1: 25 percent / AcOEt, AcOH, Et3N / 2-methyl-propan-2-ol / anodic oxidation; Pt electrodes, i = 50 mA*cm-2, current equiv.: 3.4 F/mol 2: 69 percent / 70 percent CF3COOH / H2O / 6 h / 25 °C View Scheme

sodium hydroxide in 1,4-dioxane

chloroform; ammonia

ammonium hydroxide