3-(1,3-二氧戊环-2-基)苯胺合成路线 （共 8 条）
反应条件
toluene-4-sulfonic acid in ethylene glycol; benzene
反应条件
1: With toluene-4-sulfonic acid in toluene 4 h; Reflux; 2: With sodium hydrogencarbonate in water; toluene Saturated solution; 3: With hydrogen; platinum(IV) oxide in tetrahydrofuran T=20°C; 4 h;
参考文献
US2009/291984 A1, ;
Page/Page column 20 ;
反应条件
tris(dibenzylideneacetone)dipalladium (0); lithium hexamethyldisilazane; 2-dicyclohexylphosphino-1,1'-biphenyl in tetrahydrofuran T=65°C; 15 h;
参考文献
Huang; Buchwald
Organic letters, 2001 , vol. 3, # 21 p. 3417 - 3419
反应条件
cesium fluoride in N,N-dimethyl-formamide T=45°C; 8 h;
参考文献
Mullick, Dibakar; Anjanappa, Prakash; Selvakumar, Kumaravel; Ruckmani, Kandasamy; Sivakumar, Manickam
Tetrahedron Letters, 2010 , vol. 51, # 46 p. 5984 - 5987
反应条件
ammonium chloride in water
参考文献
EP1264820 A1, ;
EP 1264820 A1
反应条件
1: 69 percent / p-toluenesulfonic acid / benzene / 3 h / Heating 2: H2 / Pd/C / ethanol; tetrahydrofuran / 3 h / 2585.74 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 16 p. 5247 - 5260
反应条件
1: triethylamine / ethyl acetate / 3.5 h / 0 - 20 °C
2: water; hydrogenchloride / 1,4-dioxane / 1.5 h / 20 - 60 °C
View Scheme
参考文献
Actelion Pharmaceuticals Ltd.; FRETZ, Heinz; Gude, Markus; Guerry, Philippe; Kimmerlin, Thierry; Lehembre, Francois; Pfeifer, Thomas; Valdenaire, Anja
Patent: US2013/345199 A1, 2013 ;
反应条件
pyridine in ethyl acetate
参考文献
Bristol-Myers Company
Patent: US4701459 A1, 1987 ;
