1-苄基-4-(4-吡啶) 哌嗪合成路线 （共 7 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol T=20°C; P=1810.07 Torr;
参考文献
Bergbreiter, David E.; Osburn, Philip L.; Li, Chunmei
Organic Letters, 2002 , vol. 4, # 5 p. 737 - 740
反应条件
copper(II) sulfate in water
T=140°C;
参考文献
Schering Corporation
Patent: US2004/106794 A1, 2004 ;
Location in patent: Page 160-161 ;
US 20040106794 A1
反应条件
sodium hydroxide; water in 1,4-dioxane
T=70°C; Substitution; P=6000480 Torr; 20 h;
参考文献
Kotsuki, Hiyoshizo; Sakai, Hiromitsu; Shinohara, Toshio
Synlett, 2000 , # 1 p. 116 - 118
反应条件
copper(II) sulfate in water
T=140°C; 24 h;
参考文献
Manetti, Dina; Bartolini, Alessandro; Borea, Pier Andrea; Bellucci, Cristina; Dei, Silvia; Ghelardini, Carla; Gualtieri, Fulvio; Romanelli, Maria Novella; Scapecchi, Serena; Teodori, Elisabetta; Varani, Katia
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 3 p. 457 - 465
反应条件
in xylene
20 h; Heating;
参考文献
Bergbreiter, David E.; Osburn, Philip L.; Li, Chunmei
Organic Letters, 2002 , vol. 4, # 5 p. 737 - 740
反应条件
1: 69 percent / KOH / methanol / Heating
2: 93 percent / xylene / 20 h / Heating
View Scheme
参考文献
Bergbreiter, David E.; Osburn, Philip L.; Li, Chunmei
Organic Letters, 2002 , vol. 4, # 5 p. 737 - 740
反应条件
1: 99 percent / NaHCO3 / aq. ethanol / 18 h / Heating
2: 69 percent / KOH / methanol / Heating
3: 93 percent / xylene / 20 h / Heating
View Scheme
参考文献
Bergbreiter, David E.; Osburn, Philip L.; Li, Chunmei
Organic Letters, 2002 , vol. 4, # 5 p. 737 - 740
