6-氨基-1-乙基-3-丙基-2,4(1H,3H)-嘧啶二酮合成路线 （共 5 条）
反应条件
in methanol; ammonium hydroxide
参考文献
Elzein, Elfatih; Kalla, Rao; Marquart, Tim; Zablocki, Jeff; Li, Xiaofen
Patent: US2004/176399 A1, 2004 ;
US 20040176399 A1
反应条件
ammonia in methanol; water
T=20°C; 72 h;
参考文献
Zeng, Dewan; Belardinelli, Luiz
Patent: US2006/58322 A1, 2006 ;
Location in patent: Page/Page column 16 ;
US 20060058322 A1
反应条件
1: N,N-dimethyl acetamide
2: potassium carbonate / N-methyl-acetamide
3: dichloromethane; aqueous ammonia; methanol
View Scheme
参考文献
Gilead Sciences, Inc.
Patent: US2012/3329 A1, 2012 ;
US 20120003329 A1
反应条件
1: potassium carbonate / N-methyl-acetamide
2: dichloromethane; aqueous ammonia; methanol
View Scheme
参考文献
Gilead Sciences, Inc.
Patent: US2012/3329 A1, 2012 ;
US 20120003329 A1
反应条件
sodium hydroxide; ethanol
参考文献
Papesch; Schroeder
Journal of Organic Chemistry, 1951 , vol. 16, p. 1879,1881,1887
