2-甲基-2-(苯基巯基)丙醛合成路线 （共 15 条）
反应条件
pyridine; thionyl chloride
T=0°C; 0.5 h;
参考文献
Groot, Aede de; Jansen, Ben J. M.
Synthesis, 1985 , # 4 p. 434 - 436
反应条件
methanol; potassium carbonate
T=0°C; 0.333333 h;
参考文献
Craig, Donald; Daniels, Kevin; MacKenzie, A. Roderick
Tetrahedron, 1993 , vol. 49, # 48 p. 11263 - 11304
反应条件
4 A molecular sieve; [S]-pyrrolidine 2-trifluoromethanesulfonamide in acetonitrile
T=20°C; 72 h;
参考文献
SCIENCE and TECHNOLOGY CORPORATION &at; UNM
Patent: WO2006/7586 A1, 2006 ;
Location in patent: Page/Page column 54-56; 106-107; 110 ;
反应条件
boron trifluoride diethyl etherate in water; acetone
96 h; Ambient temperature;
参考文献
Reese, Colin B.; Sanders, H. Paul
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 11 p. 2719 - 2724
参考文献
Imperial Chemical Industries PLC
Patent: US5053415 A1, 1991 ;
反应条件
1.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C
1.2: 93 percent / hexane; tetrahydrofuran / 0.33 h / -78 °C
2.1: 89 percent / SOCl2; Et3N / CH2Cl2 / 0.75 h / 0 °C
View Scheme
参考文献
Aggarwal, Varinder K.; Eames, Jason; Villa, Maria-Jesus; McIntyre, Sara; Sansbury, Francis H.; Warren, Stuart
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 2000 , # 4 p. 532 - 546
反应条件
in ethylene glycol dimethyl ether
1 h; Ambient temperature;
参考文献
Verhe, R.; Kimpe, N. De; Buyck, L. De; Schamp, N.
Synthesis, 1984 , # 1 p. 46 - 49
反应条件
1: 60 percent / (CF3SO2)2O, Ac2O / 0.25 h / 20 °C
2: 75 percent / K2CO3 / methanol / 0.33 h / 0 °C
View Scheme
参考文献
Craig, Donald; Daniels, Kevin; MacKenzie, A. Roderick
Tetrahedron, 1993 , vol. 49, # 48 p. 11263 - 11304
反应条件
sodium hydride
1.) DMPU, 5 deg C, 1 h, 2.) DMPU, RT, 18 h; Multistep reaction;
参考文献
Faull, Alan W.; Brewster, Andrew G.; Brown, George R.; Smithers, Michael J.; Jackson, Ruth
Journal of Medicinal Chemistry, 1995 , vol. 38, # 4 p. 686 - 694
反应条件
diisobutylaluminium hydride
参考文献
Brownbridge,P.; Warren,S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1977 , p. 1131 - 1141
