反应条件
1: 68 percent / dioxane / 16 h / 65 °C 2: 1.) KOH, 2.) H2 / 2.) 10 percent Pd/C / 1.) water, 0 deg C - RT, 2.) water, 23 h 3: 11.0 g / N-methylmorpholine, HOBT*H2O, EDC*HCl / dimethylformamide / 1.) from 0 deg C to RT, 2.) RT, 4 h View Scheme
参考文献
Sanderson, Philip E. J.; Lyle, Terry A.; Cutrona, Kellie J.; Dyer, Dona L.; Dorsey, Bruce D.; McDonough, Colleen M.; Naylor-Olsen, Adel M.; Chen, I.-Wu; Chen, Zhongguo; Cook, Jacquelynn J.; Cooper, Carolyn M.; Gardell, Stephen J.; Hare, Timothy R.; Krueger, Julie A.; Lewis, S. Dale; Lin, Jiunn H.; Lucas Jr., Bobby J.; Lyle, Elizabeth A.; Lynch Jr., Joseph J.; Stranieri, Maria T.; Vastag, Kari; Yan, Youwei; Shafer, Jules A.; Vacca, Joseph P.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4466 - 4474
