3-环丙基-2-氧代丙酸乙酯合成路线 （共 3 条）
反应条件
1: With [bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane T=-5°C; 0.333333 h; Inert atmosphere; 2: With ethanol in dichloromethane T=20°C; 15 h;
参考文献
VIROBAY, INC.; HART, Barry; DENER, Jeffrey M.; GREEN, Michael J.; STANDEN, Michael; KOCIAN, Oldrich
Patent: WO2011/22429 A2, 2011 ;
Location in patent: Page/Page column 17-18 ;
WO 2011/022429 A2
反应条件
N-bromosuccinmide in water; acetone
T=-5°C; 1.5 h;
参考文献
VIROBAY, INC.; HART, Barry; DENER, Jeffrey M.; GREEN, Michael J.; STANDEN, Michael; KOCIAN, Oldrich
Patent: WO2011/22429 A2, 2011 ;
Location in patent: Page/Page column 17 ;
WO 2011/022429 A2
反应条件
potassium hydroxide
2 h; Ambient temperature;
参考文献
Graham, Donald W.; Ashton, Wallace T.; Barash, Louis; Brown, Jeannette E.; Brown, Ronald D.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1074 - 1090
