乙基5-(4-氟苯基)-1,2-恶唑-3-羧酸酯合成路线 （共 3 条）
反应条件
1: LiAlH4 / diethyl ether / 0.5 h / 40 °C 2: PCC / CH2Cl2 / 5 h / 20 °C View Scheme
参考文献
Roy, Amrendra K.; Batra, Sanjay
Synthesis, 2003 , # 15 p. 2325 - 2330
反应条件
triethylamine in tetrahydrofuran; toluene
T=5 - 10°C; 2 h;
参考文献
GILEAD PHARMASSET, LLC; SOFIA, Michael, Joseph; KAKARLA, Ramesh; LIU, Jian; NADUTHAMBI, Devan; MOSLEY, Ralph; STEUER, Holly, Micolochick
Patent: WO2012/103113 A1, 2012 ;
Location in patent: Page/Page column 430-431 ;
反应条件
sodium tetrahydroborate in tetrahydrofuran; ethanol
T=0°C; 4 h;
参考文献
Lopopolo, Gianfranco; Fiorella, Filomena; De Candia, Modesto; Nicolotti, Orazio; Martel, Sophie; Carrupt, Pierre-Alain; Altomare, Cosimo
European Journal of Pharmaceutical Sciences, 2011 , vol. 42, # 3 p. 180 - 191
