5-(4-氟苯基)异噁唑-3-甲醇合成路线 （共 4 条）
反应条件
pyridinium chlorochromate in dichloromethane T=20°C; 5 h;
参考文献
Akbarzadeh, Tahmineh; Rafinejad, Ali; Mollaghasem, Javad Malekian; Safavi, Maliheh; Fallah-Tafti, Asal; Pordeli, Mahboobeh; Ardestani, Sussan Kabudanian; Shafiee, Abbas; Foroumadi, Alireza
Archiv der Pharmazie, 2012 , vol. 345, # 5 p. 386 - 392
反应条件
sodium tetrahydroborate in tetrahydrofuran; ethanol
T=0°C; 4 h;
参考文献
Lopopolo, Gianfranco; Fiorella, Filomena; De Candia, Modesto; Nicolotti, Orazio; Martel, Sophie; Carrupt, Pierre-Alain; Altomare, Cosimo
European Journal of Pharmaceutical Sciences, 2011 , vol. 42, # 3 p. 180 - 191
反应条件
1: NH2OH*HCl / ethanol / 1 h / Heating
2: LiAlH4 / diethyl ether / 0.5 h / 40 °C
View Scheme
参考文献
Roy, Amrendra K.; Batra, Sanjay
Synthesis, 2003 , # 15 p. 2325 - 2330
反应条件
1.1: NaH / toluene / 45 - 50 °C
1.2: toluene / 1.5 h / Heating
2.1: NH2OH*HCl / ethanol / 1 h / Heating
3.1: LiAlH4 / diethyl ether / 0.5 h / 40 °C
View Scheme
参考文献
Roy, Amrendra K.; Batra, Sanjay
Synthesis, 2003 , # 15 p. 2325 - 2330
